Senior Researcher in Clinical Genome Scale Modelling
The Novo Nordisk Foundation Center for Biosustainability (DTU Biosustain) is seeking a senior researcher with expertise in metabolic and gene regulatory modeling and omics data integration to lead research and coordinate DTU Biosustain’s work as part of the CAG Center for Endotheliomics (CAG-CE).
CAG-CE is a clinical academic group (https://gchsp.dk/) involving six hospitals and two universities in the Copenhagen Region focusing on endothelial cell metabolism in patients with critical illness such as trauma and severe infections. The aim is through genome scale mechanistic modelling and omics data analysis to develop new markers for precision medicine.
Responsibilities and tasks
As senior researcher, you will be expected to lead research, publish and attract research funding in clinical genome scale modeling, including
Network/pathway-driven analysis of omics data obtained from critically ill patients and endothelial cell culture experiments. Specifically, the applicant will be working with metabolomics, lipidomics, proteomics, genomics, fluxomics and transcriptomics data along with typical patient metadata such as age, sex, health status, etc
- Assessment, application, and development of methods for integration of multi-omics data with computational modeling in order to identify the molecular mechanisms underlying the observed phenotypes and predict therapeutic manipulation strategies. Specifically, the applicant will be expected to develop constraint-based, kinetics and gene regulatory models using the omics data.
You will also be expected to establish and supervise a small group of MSc students, PhD students and postdoctoral fellows.
As DTU Biosustains’s CAG-CE coordinator, you are expected to engage with other researchers in the center, promote the center activities at DTU, and facillitate teaching into PhD level courses and courses for clinicians as part of the CAG-CE program.
You must hold a PhD degree (or equivalent), as well as academic qualifications equivalent to those obtained by holding a position as a researcher or postdoc in the field of computational modeling and -omics data integration.
You must have previous experience in using bioinformatics, statistics, computational modeling of large-scale networks using constraint-based methods, kinetic modeling and gene regulatory network modeling (i.e discrete or Boolean modeling) to answer biological questions. Experience in developing scientific software in the major languages used at the center, namely Python, C++, R and Matlab is essential.
The CAG-CE generates omics data from both clinical patient samples and from ex vivo endothelial cell culture models. Accordingly, the you must have previous experience in applying genome scale analysis on both clinical and ex vivo omics data, including strategies for efficient data integration (transcriptomics, proteomics, metabolomics, lipidomics and fluxomics).
As a senior researcher, we expect that you already have experience in leading a research group and supervising postgraduate students. We also expect that you have have experience in teaching systems biology methods, for example in PhD courses.
In the assessment of the candidates, consideration will be given to
- Research impact and experience, funding track record, and research vision
- Experience and quality of teaching
- Societal impact
- Documented innovation activities, including commercialization and collaboration with industry
- International impact and experience
- Leadership potential and collaboration
- Communication skills
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.
Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.
You can read more about career paths at DTU here.
Further information may be obtained from Professor Lars Nielsen, e-mail: email@example.com.
Please submit your online application no later than 29 October 2020 (local time). Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:
- Application (cover letter)
- Teaching and research statement, with a focus on the “Assessment” bullets points listed above
- Documentation of previous teaching and research, as related to the “Assessment” bullet points listed above
- List of publications
- H-index, and ORCID (see e.g. http://orcid.org/)
- Diploma (MSc/PhD)
Applications and enclosures received after the deadline will not be considered.
All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.
The Novo Nordisk Foundation Center for Biosustainability (DTU Biosustain)
Recent progress in our ability to read and write genomic code, combined with advances in automation, analytics and data science, has fundamentally changed the scope and ambition of harnessing the potential of biological systems. Big data approaches and analysis of biological systems are key research instruments at the Center. DTU Biosustain utilizes these advances for microbial cell factory design to foster sustainable lifestyles in relation to three application areas: Sustainable Chemicals, Natural Products, and Microbial Foods. Learn more at biosustain.dtu.dk.
Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 12,000 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. Our main campus is in Kgs. Lyngby north of Copenhagen and we have campuses in Roskilde and Ballerup and in Sisimiut in Greenland.
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